CIR-P37. Highly soluble and efficient Beta-Sitosterol

CIR-P37 contains a unique patented combination of sitosterol and propionic acid that increases sitosterol’s solubility and improves its healthy properties

Highly soluble and efficient Beta-Sitosterol

What is β-Sitosterol?

Phytosterols are plant steroids with a structure similar to cholesterol, and are widely distributed in the plant kingdom and specially found in vegetable oil, nuts, seeds and avocados. However, they are not synthesized by the human body and therefore their presence in the body is the result of their consumption as part of the diet. 

Particularly, the β-Sitosterol is the most common dietary phytosterol. 

Beta-sitosterol is useful for the reduction of serum total cholesterol and LDL levels. In fact, beta-sitosterol has been approved by the FDA (Food and drug Administration) and EFSA (European Food Safety Authority) for that indication. Research has shown also antioxidant, antitumor, anti-inflammatory, antidiabetic, and gallstone-reducing activities

What problems can we find?

Standard sitosterol has low bioavailability and low water solubility, being normally used in ester form and added to high-fat foods, doubling manufacturing cost and resulting in stability issues and off-flavour formation.

CIR-P37. Highly soluble and efficient Beta-Sitosterol

CIR-P37, by combining sitosterol with propionic acid on a molecular level, improves its water solubility 7 times, making it much more efficient than other existing alternatives and improving sitosterol natural healthy benefits. Sitosterol cocrystal reduced the cholesterol increase much better than sitosterol itself in in vivo study in hamsters fed with an obesogenic diet (22 days), with equivalent doses.

It also provides consumers conveniently with additional health benefits, as it has been demonstrated that Propionic Acid lowers fatty acids content in liver and plasma, reduces food intake, exerts immunosuppressive actions and probably improves tissue insulin sensitivity.

These sitosterol cocrystals have also shown other relevant health effects such as: 

  • Decrease levels of hepatosteatosis biomarkers (lower GPT levels)
  • Improved effect on obesity

You can find more information about our research at https://pubs.rsc.org/en/content/articlelanding/2020/ce/d0ce00704h#!divAbstract