Coenzyme Q10 (CoQ10 or ubiquinone) is a vitamin-like nutrient, ubiquitously present in almost all cells, which plays an essential role in the energy production of cells through the respiratory chain in mitochondria. Ubiquinol is the reduced form of ubiquinone, more bioavailable but highly unstable.
Ubiquinol is vital for providing energy to cells, helping organs perform at their best, protecting cells and blood from oxidation. As the body ages, the natural Ubiquinol levels slowly decline. These important biological roles have motivated the use of Ubiquinol as dietary supplements for improving body protection against aging by oxidative stress with a particular focus on heart and neurodegenerative diseases.
However, the oral bioavailability of the highly lipophilic coenzyme Q10 is very low with an extremely poor aqueous solubility (0.7 ng/ml). Moreover, it shows a chemical instability upon exposure to air, light and high temperature, which makes it difficult to prepare efficient pharmaceutical formulations.
Through cocrystal engineering, CIRCE has developed a unique patented combination of ubiquinol and protocatechuic acid (PCA) that stabilizes ubiquinol, avoiding its oxidation into ubiquinone and also making it 25% more bioavailable.
Health benefits
CIRCE cocrystal Ubiquinol provides unique additional health benefits:
You can find more information about our research at: https://pubs.acs.org/doi/10.1021/acs.cgd.0c00749
