ubiquinol

What is Ubiquinol ?

Coenzyme Q10 (CoQ10 or ubiquinone) is a vitamin-like nutrient, ubiquitously present in almost all cells, which plays an essential role in the energy production of cells through the respiratory chain in mitochondria. Ubiquinol is the reduced form of ubiquinone, more bioavailable but highly unstable.

Ubiquinol properties

Ubiquinol is vital for providing energy to cells, helping organs perform at their best, protecting cells and blood from oxidation. As the body ages, the natural Ubiquinol levels slowly decline. These important biological roles have motivated the use of Ubiquinol as dietary supplements for improving body protection against aging by oxidative stress with a particular focus on heart and neurodegenerative diseases.

 

However, the oral bioavailability of the highly lipophilic coenzyme Q10 is very low with an extremely poor aqueous solubility (0.7 ng/ml). Moreover, it shows a chemical instability upon exposure to air, light and high temperature, which makes it difficult to prepare efficient pharmaceutical formulations.

CIRCE Ubiquinol

Through cocrystal engineering, CIRCE has developed a unique patented combination of ubiquinol and protocatechuic acid (PCA) that stabilizes ubiquinol, avoiding its oxidation into ubiquinone and also making it 25% more bioavailable.

 

Health benefits 

CIRCE cocrystal Ubiquinol provides unique additional health benefits:

High stability to oxidation

More sophisticated and unexpensive formulation

No toxicity concerns

25% more bioavailable

You can find more information about our research at: https://pubs.acs.org/doi/10.1021/acs.cgd.0c00749

Scientific news and publications

Pterostilbene is a molecule that is naturally found in vegetables, nuts and fruits, particularly blueberries. Read more
An Aging Population Presents Opportunities for the Longevity Supplement Market As the world’s population ages, Read more
New CIRCE scientific paper published: A Novel, Extremely Bioavailable Cocrystal of Pterostilbene CIRCE has also Read more