CIR-P57. Highly stable ubiquinol (CoQ10)

CIR-P57 is a unique combination of ubiquinol and protocatechuic acid (PCA) that stabilizes ubiquinol, avoiding its oxidation into ubiquinone and also making it 25% more bioavailable

CIR-P57. Highly stable ubiquinol (CoQ10)

What is CoQ10?

Coenzyme Q10 (CoQ10 or ubiquinone) is a vitamin-like nutrient, ubiquitously present in almost all cells, which plays an essential role in the energy production of all cells through the respiratory chain in mitochondria. Ubiquinol is the reduced form of ubiquinone, more bioavailable but highly unstable. 

These important biological roles have motivated their use as dietary supplements for improving body protection against aging by oxidative stress with a particular focus on heart and neurodegenerative diseases.

What problems can we find?

Supplements are necessary for adults because the natural production of coenzyme Q10 reduces with age and because usual diet in humans provides only small amounts of this important nutrient. 

However, the oral bioavailability of the highly lipophilic coenzyme Q10 is very low with an extremely poor aqueous solubility (0.7 ng/ml). Moreover, it shows a chemical instability upon exposure to air, light and high temperature, which makes difficult to prepare efficient pharmaceutical formulations.

Most pharmaceutical formulations of CoQ10 experience different ways of degradation and the only efficient way of preventing oxidation to ubiquinone is formulated in gelatine capsules prepared under nitrogen atmosphere, a procedure which increases the manufacturing costs.

CIR-P57. Highly stable ubiquinol

A new multicomponent solid form of ubiquinol discovered by CIRCE has shown a remarkable stability to oxidation, which could offer a straightforward and inexpensive alternative, with no toxicity concerns, to more sophisticated and expensive formulations of this important nutraceutical.

You can find more information about our research at https://pubs.acs.org/doi/10.1021/acs.cgd.0c00749