Vitamin D3

CIRCE has patented a unique combination of  Vitamin D3 and resorcinol that increases its stability and solubility.

CIR-P60. Highly stable Vitamin D3

What is Vitamin D?

Vitamin D is not a single compound but a group of vitamins, being the prohormones ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), the main sources for the hydroxylated metabolites which are active in animals.

Ergocalciferol is widely available from plants and fungi while cholecalciferol is formed from UV irradiation in the animal skin. 

Vit D is important for maintaining calcium levels and promoting bone health and development, but a large and still growing amount of research has found that Vitamin D3 also stimulates immune system and is beneficial in respiratory tract infections (e.g. COVID).

CIR-P60. Highly stable Vitamin D3

What problems can we find?

Vitamin D3 is highly unstable and has low water solubility. Its degradation in multivitamin supplements usually leads to non compliance of the label. To avoid that, overages are added.

Vitamin D3 is also essential in feed to ensure the animals health. Vitamin D3 is added in premixes, where the degradation is even higher due to the aggressive environment

CIR-P60. Highly stable Vitamin D3

A new crystalline form of Vitamin D3 (Cholecalciferol) and resorcinol has been discovered and characterized through experimental screening. Its high stability has been studied against light, heat and chemicals present in animal food premixes, in order to develop a novel and alternative formulation to current microencapsulation approaches to protect vitamin D from oxidation. 

Our results show that the new crystalline form is extremely stable and it can become the basis for very efficient formulations of Vitamin D3 which fulfils the stability requirements of industrial applications.

You can find more information about our research at

Photostability test Vitamin D3 vs. CIR-P60

Stability test formulated Vitamin D3 vs. CIR-P60 in premix

Scientific news and publications

Pterostilbene is a molecule that is naturally found in vegetables, nuts and fruits, particularly blueberries. Read more
An Aging Population Presents Opportunities for the Longevity Supplement Market As the world’s population ages, Read more
New CIRCE scientific paper published: A Novel, Extremely Bioavailable Cocrystal of Pterostilbene CIRCE has also Read more