sitosterol

What is β-Sitosterol?

Phytosterols are plant steroids with a structure similar to cholesterol, and are widely distributed in the plant kingdom and specially found in vegetable oil, nuts, seeds and avocados. However, they are not synthesized by the human body and therefore their presence in the body is the result of their consumption as part of the diet. 

Particularly, the β-Sitosterol is the most common dietary phytosterol. 

Beta-sitosterol is useful for the reduction of serum total cholesterol and LDL levels. In fact, beta-sitosterol has been approved by the FDA (Food and drug Administration) and EFSA (European Food Safety Authority) for that indication. Research has shown also antioxidant, antitumor, anti-inflammatory, antidiabetic, and gallstone-reducing activities

Sitosterol properties

Beta-sitosterol is useful for the reduction of serum total cholesterol and LDL levels. In fact, beta-sitosterol has been approved by the FDA (Food and drug Administration) and EFSA (European Food Safety Authority) for that indication. Research has also shown antioxidant, antitumor, anti-inflammatory, antidiabetic, and gallstone-reducing activities.

However, standard sitosterol has low bioavailability and low water solubility, being normally used in ester form and added to high-fat foods, doubling manufacturing cost and resulting in stability issues and off-flavour formation.

Standard sitosterol has low bioavailability and low water solubility, being normally used in ester form and added to high-fat foods, doubling manufacturing cost and resulting in stability issues and off-flavour formation.

CIRCE Scientific Beta-Sitosterol​

Through cocrystal engineering, CIRCE Scientific has developed a unique patented combination of sitosterol and propionic acid which on a molecular level, improves its water solubility 7 times, making it much more efficient than other existing alternatives and improving sitosterol natural health benefits. Sitosterol cocrystal reduced the cholesterol increase much better than sitosterol itself in in vivo study in hamsters fed with an obesogenic diet (22 days), with equivalent doses.

These sitosterol cocrystals have also shown other relevant health effects such as: 

 

  • decrease levels of hepatosteatosis biomarkers (lower GPT levels)
  • Improved effect on obesity

You can find more information about our research at https://pubs.rsc.org/en/content/articlelanding/2020/ce/d0ce00704h#!divAbstract

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